For many enterprises, the venerable mainframe is home to decades’ worth of data about the company’s customers, processes and operations. And it goes without saying that the business would like access to that mainframe data — to report on it, to analyze it with big data analysis tools, or to use it as the basis of new machine learning and artificial intelligence initiatives.

At Google Cloud, we are eager to work with organizations to help them transform their mainframe assets for the cloud era. Of course, we can help them modernize their mainframe applications by migrating them to the cloud. At the same time, working with partners and customers, we’ve developed another, more lightweight approach that can help them start to leverage the cloud for their mainframe assets much more quickly than performing a full-fledged migration. We call this approach data-first digitization.   

In this rapidly evolving digital ecosystem, it’s imperative to understand the difference between ‘modernization’ and ‘digitization.’ With modernization you start with the current state and look forward, and rely on mainframe application migration approaches such as rehosting (emulation), refactoring (automated code transformation), reengineering — or simply replacing a custom application with a commercial package. With digitization, you start with the future state that you want to achieve, and work back to what is required to get there.

This data-first digitization approach includes a mainframe data-first integration framework comprising in-house and partner products and tools to migrate heterogeneous data sources from the mainframe to Google Cloud Storage. Once mainframe data has been copied to Cloud Storage, it can then be integrated and leveraged by Google Cloud tools such as BigQuery, AI and machine learning prodcuts  and Smart and Stream analytics platforms. The integration framework covers both bulk batch data transfers and real-time data replication (change data capture).

Data-first digitization is based on the tenet that ‘applications are transient, data is permanent.’ By bringing data first to Google Cloud instead of traditional ways of modernizing applications (for example, with Gartner’s 7 options to Modernize), this allows organizations to leapfrog to new business models, use cases and innovative ways to serve end customers. For example:

• Making decisions with smart and stream analytics platforms and AI/ML engines. These tools need data to make decisions. Google is a pioneer in extracting information and value from the raw structured and unstructured data, and this approach opens up mainframe data for use by BigQuery and AI/ML models. 
• Building new reporting applications. With access to mainframe data, you can use Google cloud products like Looker and Appsheet to build net-new reporting applications, expediting the process of retiring mainframe reporting applications, and accelerating your overall transformation.

In our experience, taking a data-first digitization approach to your mainframe offers a number of benefits:

1. Faster time-to-business: Because data-first modernization is built on existing products, the implementation cycle is much shorter.
2. Less capital investment: You spend your time integrating products, not developing applications.
3. Minimized risk: Data-first integrates with existing, proven and reliable Google Cloud products.
4. Faster overall mainframe transformation: When you shift your modernization center of gravity from the application to the data, you look at mainframe applications from a business perspective instead of just “keeping the lights on.” As a result, only the most business-critical applications are modernized and many support applications can be decommissioned, accelerating your transformation journey. 

Taking a data-first approach to digitization is still relatively new, but we’re heartened by customers’ early successes. Watch this space for additional insights, reference architectures and technical white papers around data-first. And if you think this approach may be right for you, reach out to mainframe@google.com.

Learn more:

• Liberating your mainframe data with Confluent and Google Cloud
• Beyond mainframe modernization: The art of possibilities

In the past decade, the Healthcare and Life Sciences industry has enjoyed a boon in technological and scientific advancement. New insights and possibilities are revealed almost daily. At Google Cloud, driving innovation in cloud computing is in our DNA. Our team is dedicated to sharing ways Google Cloud can be used to accelerate scientific discovery. For example, the recent announcement of AlphaFold2 showcases a scientific breakthrough, powered by Google Cloud, that will promote a quantum leap in the field of proteomics. In this blog, we’ll review another omics use case, single-cell analysis, and how Google Cloud’s Dataproc and NVIDIA GPUs can help accelerate that analysis.

The Need for Performance in Scientific Analysis

The ability to understand the causal relationship between genotypes and phenotypes is one of the long-standing challenges in biology and medicine. Understanding and drawing insights from the complexity of biological systems abounds from the actual code of life (DNA) through to expression of genes (RNA) to translation of gene transcripts into proteins that function in different pathways, cells, and tissues within an organism. Even the smallest of changes in our DNA can have large impacts on protein expression, structure, and function, which ultimately drives development and response – at both cellular and organism levels. And, as the omics space becomes increasingly data- and compute-intensive, research requires an adequate informatics infrastructure. An infrastructure that scales with growing data demands, enables a diverse range of resource-intensive computational activities, and is affordable and efficient – reducing data bottlenecks and enabling researchers to maximize insight. 

But where do all these data and compute challenges come from and what makes scientific study so arduous? The layers of biological complexity begin to be made apparent immediately when looking at not just the genes themselves, but their expression. Although all the cells in our body share nearly identical genotypes, our many diverse cell types (e.g. hepatocytes versus melanocytes) express a unique subset of genes necessary for specific functions, making transcriptomics a more powerful method of analysis by allowing researchers to map gene expression to observable traits. Studies have shown that gene expression is heterogeneous, even in similar cell types. Yet, conventional sequencing methods require DNA or RNA extracted from a cell population. The development of single-cell sequencing was pivotal to the omics field. Single-cell RNA sequencing has been critical in allowing scientists to study transcriptomes across large numbers of individual cells. 

Despite its potential, and the increasing availability of single-cell sequencing technology, there are several obstacles: an ever increasing volume of high-dimensionality data, the need to integrate data across different types of measurements (e.g. genetic variants, transcript and protein expression, epigenetics) and across samples or conditions, as well as varying levels of resolution and the granularity needed to map specific cell types or states. These challenges present themselves in a number of ways including background noise, signal dropouts requiring imputation, and limited bioinformatics pipelines that lack statistical flexibility. These and other challenges result in analysis workflows that are very slow, prohibiting the iterative, visual, and interactive analysis required to detect differential gene activity. 

Accelerating Performance

Cloud computing can help not only with data challenges, but with some of the biggest obstacles: scalability, performance, and automation of analysis. To address several of the data and infrastructure challenges facing single-cell analysis, NVIDIA developed end-to-end accelerated single-cell RNA sequencing workflows that can be paired with Google Cloud Dataproc, a fully-managed service for running open source frameworks like Spark, Hadoop, and RAPIDS. The Jupyter notebooks that power these workflows include examples using samples like human lung cells and mouse brains cells and demonstrate acceleration between CPU-based processing compared to GPU-based workflows. 

Google Cloud Dataproc powers the NVIDIA GPU-based approach and demonstrates data processing capabilities and acceleration, which in turn have the potential of delivering considerable performance gains.  When paired with RAPIDS, practitioners can accelerate data science pipelines on NVIDIA GPUs, reducing operations like data loading, processing, and training from hours to seconds. RAPIDS abstracts the complexities of accelerated data science by building upon popular Python and Java libraries effortlessly. When applying RAPIDS and NVIDIA accelerated compute to single-cell genomics use cases, practitioners can churn through analysis of a million cells in only a few minutes.

Give it a Try

The journey to realizing the full potential of omics is long; but through collaboration with industry experts, customers, and partners like NVIDIA, Google Cloud is here to help shine a light on the road ahead. To learn more about the notebook provided for single-cell genomic analysis, please take a look at NVIDIA’s walkthrough. To give this pattern a try on Dataproc, please visit our technical reference guide.